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  • PIIIP RIA

Procollagen-III-peptide (PIIIP) radioimmunometric assay kit

The OCFK07-PIIIP test enables the determination of human procollagen III peptide. It is based on the principle of a very easy to use sandwich assay. The 20 ?l blood sample is convenient for patients. The transformation of functioning liver tissue into connective tissue is detectable through a raised serum procollagen III peptide level. This is the case, for instance, in alcoholic or virus induced forms of liver fibrosis. The parameter is suitable for monitoring the course of liver disorders and particularly in psoriatic patients treated by Methotrexate. The procollagen III peptide determination enables to reduce the number of biopsy for a better patient comfort and cost savings. Related product: HYAL-ELISA ( Hyaluronic acid ELISA assay)

Features

  • Working range: 0 ? 14 U/mL (?g/mL = CIS U/mL x 8)
  • Sample: serum or plasma ? 20 ?L
  • Analytical sensitivity: 0.1 U/mL

Applications

  • N-terminal procollagen-III-peptide (PIIIP), the fibrosis marker in liver diseases
  • Elevated serum PIIIP concentrations are found in alcohol-induced or viral hepatic fibrosis and cirrhosis
  • Raised PIIIP levels are encountered in pulmonary fibrosis and Paget’s disease, chronic polyarthritis and collagenosis
  • Monitoring the course of disease over time
  • Correlation with histological findings in fibrosis and cirrhosis
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Ref: OCFK07-PII

Assay principle

RIA

Coated tubes

Two monoclonal anti-PIIIP antibodies are used for the sandwich. The first monoclonal antibody is adsorbed onto the tube walls, while the second monoclonal antibody is radiolabelled with iodine-125.
*Two-step assay procedure: 2h at RT / shaking + 3h at RT / shaking.

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