The RENIN III GENERATION assay is a one step protocol taking 3 hours, and offering laboratories an attractive easy to use assay in comparison with plasma renin activity (PRA) .Numerous studies demonstrated the good correlation between PRA and active renin, thus offering an easy conversion from PRA methods.
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- Active renin RIA
Active renin radioimmunometric assay kit (RENIN III GENERATION)
Features
- Working range: 0 ? 320 pg/mL (IRP 68/356 IU = CIS pg/mL x 1,8.10-6)
- Sample: EDTA Plasma; 300 ?L
- Analytical sensitivity: 1 pg/mL
- Functional sensitivity: 5 pg/mL
Applications
- Assessment and follow-up of hypertensive patients
- Differential diagnosis between primary and secondary hyperaldosteronism
- Assessment of insufficient response to antihypertensive treatment
- Diagnosis of unilateral stenosis of the renal artery
- Detection of an ectopic production of renin in cases of cancer associated with hypertension
- The Endocrine Society * recommends determining the aldosterone/renin ratio to detect primary aldosteronism
- *Funder JW et al.J Clin Endocrinol Metab.2008 ;93(9) :3266-81
Assay principle
IRMA
Coated tubes
Two monoclonal antibodies are used for the sandwich. The first monoclonal antibody is coated onto the walls of the tube, while the second monoclonal antibody is radiolabelled with iodine-125.
*One-step assay procedure: 3h at RT / shaking.