The OCFK07-PIIIP test enables the determination of human procollagen III peptide. It is based on the principle of a very easy to use sandwich assay. The 20 ?l blood sample is convenient for patients. The transformation of functioning liver tissue into connective tissue is detectable through a raised serum procollagen III peptide level. This is the case, for instance, in alcoholic or virus induced forms of liver fibrosis. The parameter is suitable for monitoring the course of liver disorders and particularly in psoriatic patients treated by Methotrexate. The procollagen III peptide determination enables to reduce the number of biopsy for a better patient comfort and cost savings. Related product: HYAL-ELISA ( Hyaluronic acid ELISA assay)
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- PIIIP RIA
Procollagen-III-peptide (PIIIP) radioimmunometric assay kit
Features
- Working range: 0 ? 14 U/mL (?g/mL = CIS U/mL x 8)
- Sample: serum or plasma ? 20 ?L
- Analytical sensitivity: 0.1 U/mL
Applications
- N-terminal procollagen-III-peptide (PIIIP), the fibrosis marker in liver diseases
- Elevated serum PIIIP concentrations are found in alcohol-induced or viral hepatic fibrosis and cirrhosis
- Raised PIIIP levels are encountered in pulmonary fibrosis and Paget’s disease, chronic polyarthritis and collagenosis
- Monitoring the course of disease over time
- Correlation with histological findings in fibrosis and cirrhosis
작용원리
RIA
Coated tubes
두개의 단일클론성 anti-PIIIP 항체는 샌드위치법에 사용된다.
첫번째 단일클론성 항체는 튜브 벽에 흡착되어 있고, Iodine 125가 표지된 두번째 단일클론성 항체는 추적자로 사용된다.
*2 step 검사 절차: RT(실온)에서 2시간 / Shaking + RT(실온)에서 3시간 / Shaking.