Based on our expertise in immunoassays, Cisbio Bioassays developed a Chromogranin A immunoradiometric assay by selecting antibodies targeting the core of the molecule (145-245) relatively unaffected by proteolysis. This antibody choice and the analytical accuracy of the assay mean high analytical and clinical performances in testing for neuroendocrine tumors. Chromogranin A measurements in neuroendocrine tumors are established in the guidelines* as an aid for diagnosis, treatment efficiency and prognostic factors. The CGA-RIACT assay gives numerous analytical and clinical benefits, as shown in references in the literature, and is easy to install and operate in laboratories. *guidelines
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- In-Vitro Diagnostics
- Oncology
- CgA RIA
Chromogranin A (CGA) immunoradiometric assay kit
Features
- Working range: 0 ? 1200 ng/mL
- Sample: serum or plasma ? 50 ?L
- Analytical sensitivity: 1.5 ng/mL
Applications
- High specificity and sensitivity in neuroendocrine tumors
- Diagnosis and follow-up in neuroendocrine tumors such as pheochromocytoma, gastrinoma, and carcinoid tumors
- Diagnosis and management of Small-Cell lung carcinomas (SCLC)
- Adverse prognostic factor in prostate cancer independent of PSA
- Diagnosis and management of ectopic Cushing’s syndrome
작용원리
IRMA
Coated tubes
두개의 단일클론성항체는 샌드위치법에 사용되고, 단백질 분해에 덜 민감한 분자의 중심 영역(145-245)을 향해 유도된다.
첫번째 단일클론성 항체는 튜브벽에 흡착되어 있고, Iodine 125가 표지된 두번째 단일클론성 항체는 추적자로 사용된다.
*2 step 검사 절차: RT(실온)에서 18시간 + RT(실온)에서 2시간 / Shaking.