The IRMA-HCT assay offers a specific measurement of mature calcitonin without cross-reactivity with proCT. The assay kit has been developed to reach an optimized functional sensitivity of 4pg/mL and offers an extended range of 0-1500 pg/mL.
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- hCT RIA
Human calcitonin (hCT) immunoradiometric assay kit
Features
- Working range: 1.5 ? 1500 pg/mL (1?IU 2nd IS 89/620 = 3.6 pg CIS)
- Sample: serum pretreated by heating 30 min at 56°C ? 200 ?L
- Analytical sensitivity: 1.5 pg/mL
- Functional sensitivity: 4.0 pg/mL
Applications
- Diagnosis and follow-up of medullary thyroid carcinoma (MTC)
- hCT measurements and pentagastrin test (Pg test) are systematically carried out for an early diagnosis of cancer in at-risk families or in case of relapse among previously-operated patients.
- hCT doubling time as a powerful prognosis factor in MTC-affected patients
- Adjunct to diagnosis of multiple endocrine neoplasia type II and familial MTC
- Occasionally useful in the diagnosis and follow-up of islet cell tumors
작용원리
IRMA
Coated tubes
두개의 단일클론성 항체는 샌드위치법에 사용된다.
첫번째 단일클론성 항체는 튜브 벽에 흡착되어 있고, Iodine 125가 표지된 두번째 단일클론성 항체는 추적자로 사용된다.
*1 step 검사 절차: RT(실온)에서 20시간.