The RENIN III GENERATION assay is a one step protocol taking 3 hours, and offering laboratories an attractive easy to use assay in comparison with plasma renin activity (PRA) .Numerous studies demonstrated the good correlation between PRA and active renin, thus offering an easy conversion from PRA methods.
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- 제품소개
- In-Vitro Diagnostics
- Endocrinology / Hypertension
- Active renin RIA
Active renin radioimmunometric assay kit (RENIN III GENERATION)
Features
- Working range: 0 ? 320 pg/mL (IRP 68/356 IU = CIS pg/mL x 1,8.10-6)
- Sample: EDTA Plasma; 300 ?L
- Analytical sensitivity: 1 pg/mL
- Functional sensitivity: 5 pg/mL
Applications
- Assessment and follow-up of hypertensive patients
- Differential diagnosis between primary and secondary hyperaldosteronism
- Assessment of insufficient response to antihypertensive treatment
- Diagnosis of unilateral stenosis of the renal artery
- Detection of an ectopic production of renin in cases of cancer associated with hypertension
- The Endocrine Society * recommends determining the aldosterone/renin ratio to detect primary aldosteronism
- *Funder JW et al.J Clin Endocrinol Metab.2008 ;93(9) :3266-81
작용원리
IRMA
Coated tubes
두개의 단일클론성 항체는 샌드위치법에 사용된다.
첫번째 단일클론성 항체는 튜브 벽에 흡착되어 있고, Iodine 125가 표지된 두번째 단일클론성 항체는 추적자로 사용된다.
*1 step 검사 절차: RT(실온)에서 3시간 / Shaking.